When you stay at Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG in Cape Girardeau, you'll be near the airport, within a 10-minute drive of Shawnee National Forest and Mississippi River. This spa hotel is 0.5 mi (0.8 km) from Saint Francis Medical Center and 2.4 mi (3.8 km) from Cape Splash Family Aquatic Center.

Make yourself at home in one of the 102 guestrooms featuring microwaves and flat-screen televisions. Your pillowtop bed comes with down comforters and premium bedding. Complimentary wired and wireless internet access keeps you connected, and cable programming provides entertainment. Private bathrooms have complimentary toiletries and hair dryers.

Take time to pamper yourself with a visit to the full-service spa. If you're looking for recreational opportunities, you'll find an indoor pool and a fitness center. Additional features at this hotel include complimentary wireless internet access, a banquet hall, and a vending machine.

A complimentary breakfast is included.

Featured amenities include complimentary wired internet access, a business center, and complimentary newspapers in the lobby. Planning an event in Cape Girardeau? This hotel has 118 square feet (11 square meters) of space consisting of conference space and a meeting room. Free self parking is available onsite.

• Extra-person charges may apply and vary depending on property policy
• Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
• Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
• This property accepts credit cards; cash is not accepted
• Cashless transactions are available
• Safety features at this property include a fire extinguisher and a smoke detector
• This property affirms that it follows the cleaning and disinfection practices of Clean Promise (IHG)

Front desk staff will greet guests on arrival at the property. Information provided by the property may be translated using automated translation tools.

• Pool access available from 8 AM to 11 PM.
• The property has connecting/adjoining rooms, which are subject to availability and can be requested by contacting the property using the number on the booking confirmation.
• Cashless payment methods are available for all transactions.
• Contactless check-in and contactless check-out are available.
• This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).