Located in Santee, Comfort Inn & Suites Santee is in the entertainment district, within a 5-minute drive of Santee Cooper Country Club and Santee National Golf Club. This hotel is 1.2 mi (1.9 km) from Santee Town Hall and 1.4 mi (2.2 km) from Santee State Park.

Stay in one of 61 guestrooms featuring plasma televisions. Your pillowtop bed comes with Frette Italian sheets. Complimentary wireless internet access keeps you connected, and satellite programming is available for your entertainment. Bathrooms have shower/tub combinations and hair dryers.

Take advantage of recreation opportunities including a fitness center and a seasonal outdoor pool. Additional features at this hotel include complimentary wireless internet access, a fireplace in the lobby, and a vending machine.

A complimentary buffet breakfast is included.

Featured amenities include a business center, complimentary newspapers in the lobby, and a 24-hour front desk. Free self parking is available onsite.

• Extra-person charges may apply and vary depending on property policy
• Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
• Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
• The name on the credit card used at check-in to pay for incidentals must be the primary name on the guestroom reservation
• This property accepts credit cards; cash is not accepted
• This property reserves the right to pre-authorize the guest's credit card prior to arrival.
• Only bookings from non-local guests are accepted; guests whose residence is within 45 mi (72 km) of the property will not be allowed to check in
• This property affirms that it follows the cleaning and disinfection practices of Commitment to Clean (Choice)
• Please note that cultural norms and guest policies may differ by country and by property; the policies listed are provided by the property

Front desk staff will greet guests on arrival at the property. The credit card used to book the reservation must be presented by the cardholder at check-in along with matching photo identification. Other arrangements must be coordinated with the property prior to arrival. Information provided by the property may be translated using automated translation tools.

• The seasonal pool will be open from March to October.
• Pool access available from 10 AM to 10 PM.
• Children 15 years old and younger stay free when occupying the parent or guardian's room, using existing bedding.
• The property has connecting/adjoining rooms, which are subject to availability and can be requested by contacting the property using the number on the booking confirmation.